3-(3,5-Bis(trifluoromethyl)benzylamino)propanol → N-[3,5-bis(trifluoromethyl)benzyl]-N-(2-hydroxyethyl)amine

HRID 2296879Notes

Reaction equation

HRID 2296879 reaction equation
ClC1C([C:8](O)=[O:9])=C(C2C=CC=CC=2)C(C)=CN=1.[F:18][C:19]([F:37])([F:36])[C:20]1[CH:21]=[C:22]([CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1)[CH2:23][NH:24][CH2:25]CCO>>[F:35][C:32]([F:34])([F:33])[C:30]1[CH:29]=[C:22]([CH:21]=[C:20]([C:19]([F:37])([F:36])[F:18])[CH:31]=1)[CH2:23][NH:24][CH2:25][CH2:8][OH:9]

Participants

3

Reactant 2

HCID 116380193-(3,5-Bis(trifluoromethyl)benzylamino)propanolHCID 183872502-Chloro-5-methyl-4-phenyl-3-pyridinecarboxylic acid

Product 1

HCID 22248766N-[3,5-bis(trifluoromethyl)benzyl]-N-(2-hydroxyethyl)amine

Procedure

2-Chloro-5-methyl-4-phenyl-3-pyridinecarboxylic acid was used in place of 2-chloro-4-phenyl-3-pyridinecarboxylic acid in Step 2 in Reference Example 12, reacted with N-[3,5-bis(trifluoromethyl)benzyl]-N-(3-hydroxypropyl)amine that had been obtained in Step 1 in Reference Example 23, in place of N-[3,5-bis(trifluoromethyl)benzyl]-N-(2-hydroxyethyl)amine, and treated in the same manner as in Step 2 in Reference Example 12, to obtain the entitled compound as a pale yellow oil.

Sources & evidence

ORD record
ord-299ef73a3c35446f85d304128ae8a04b
Source dataset
uspto-grants-2002_12
Patent number
US06489315B1

Reaction notes

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