HCID 22997353, compound → HCID 22997334, compound

Participants

Reaction Steps

1.8 g of 2,2-bis-[4-(4-nitrobenzylamino)carbonylmethoxyphenyl]propane are dissolved in 300 ml of THF and, after addition of 0.5 g of palladium charcoal (10%), are hydrogenated in a bypass apparatus until the starting compound can no longer be detected (TLC). After the catalyst has been filtered off with suction, the filtrate is concentrated to dryness in vacuo and the residue is chromatographed through a silica gel column using a mixture of dichloromethane/ethanol, 95:5. The chromatographically pure fractions are combined and concentrated, and the residue is dried under high vacuum. 1.05 g of the title compound are obtained in the form of a solidified foam.

Provenance & Evidence