HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Ethyl-1H-pyrrole-3-carboxylic acid | HCID 22737923 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate | HCID 12146426 | — |
Reaction Steps
Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489473B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-1518214905394e788170e34add59507a |
| Source note | uspto-grants-2002_12 |