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Triethylamine → Ethyl 3-(4-methyl-3-pyrrolecarboxamido)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Methyl-1H-pyrrole-3-carboxylic acid | HCID 274408 | — |
| 反応物 | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 3-(4-methyl-3-pyrrolecarboxamido)propionate | HCID 12146427 | 43.1% |
反応手順
Using 7.63 g (60 mmol) of 4-methyl-3-pyrrolecarboxylic acid, 15.4 g (100 mmol) of β-alanine ethyl ester hydrochloride, 14 ml (100 mmol) of triethylamine, 17.3 g (90 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 100 ml of methylene chloride, 5.80 g of the title compound were obtained in a similar manner as in Example 2 (yield: 26%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06489473B2 |
| 出典データセット | uspto-grants-2002_12 |
| ORD ID | ord-edaae9ef8466469da585d6d6ca5e7882 |
| 出典メモ | uspto-grants-2002_12 |