反应详情

To a suspension of 14.52 g (0.10 mol) of 3-acetylbenzonitrile in 100 ml of methanol was added 17.56 g (0.11 mol) of O-benzylhydroxyamine hydrochloride and further added dropwise 9.49 g (0.12 mol) of pyridine. The mixture was stirred at room temperature for 2.5 hours, and most of the methanol was distilled off. To the residue was added ethyl acetate and resultant mixture was washed successively with about 5% aqueous hydrochloric acid twice, an about 5% aqueous solution of sodium bicarbonate once, and water once, then dried and concentrated to obtain 24.15 g (95.0 mmol) of crude 3-(1-(benzyloxyimino)ethyl)benzonitrile.

1. distillationmost of the methanol was distilled off
2. additionTo the residue was added ethyl acetate and resultant mixture
3. washwas washed successively with about 5% aqueous hydrochloric acid twice
4. dry with materialan about 5% aqueous solution of sodium bicarbonate once, and water once, then dried
5. concentrationconcentrated