反应详情

To a solution of 24.4 g (0.1214 mol) of 5-bromo-2-methylbenzylalcohol in 200 ml of dry diethyl ether was added dropwise 16.4 g (0.06067 mol) of phosphorous tribromide over 30 minutes with ice-cooling. After the mixture was stirred for 3 hours with ice-cooling, the reaction mixture was added to ice water (500 ml), and the mixture was separated. The organic layer was washed successively with water, a saturated aqueous solution of sodium bicarbonate and saturated brine, then dried and concentrated to obtain 29.07 g of 5-bromo-2-methylbenzylbromide as crystals.

1. temperaturecooling
2. temperaturecooling
3. customthe mixture was separated
4. washThe organic layer was washed successively with water
5. dry with materiala saturated aqueous solution of sodium bicarbonate and saturated brine, then dried
6. concentrationconcentrated