Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Diethyl phosphonomethanol | HCID 76513 | — |
| Reactant | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57108520 | HCID 57108520 | — |
Reaction Steps
A solution of diethyl hydroxymethylphosphonate (1 mmole) in DMF was treated with sodium hydride (1.2 mmole) followed by 2-methyl-4-chloromethylthiazole (1 mmole) at 0° C. and stirred at 25° C. for 12 h. Extraction and chromatography gave 2-methyl-4-(diethylphosphonomethoxymethyl)thiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06489476B1 |
|---|
| Source dataset | uspto-grants-2002_12 |
|---|
| ORD ID | ord-e6356f414a6e40e680cee5d417446f89 |
|---|
| Source note | uspto-grants-2002_12 |
|---|
