HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dihydro-3-oxo-1-isobenzofuranacetic acid → 2-(3-Phthalidyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dihydro-3-oxo-1-isobenzofuranacetic acid | HCID 589730 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Phthalidyl)ethanol | HCID 22274970 | — |
Reaction Steps
A solution of phthalide-3-acetic acid (1 mmole) in THF was treated with borane dimethylsulfide (1.5 mmole) at 0° C. for 1 h, and at 25° C. for 24 h. Extraction and chromatography gave 2-(3-phthalidyl)ethanol as a light yellow oil: Rf=0.25, 50% EtOAc-hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489476B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-e3627dafed27453aaff2cd56290c5f72 |
| Source note | uspto-grants-2002_12 |