HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl phosphonomethanol → 2-Diethylphosphonomethyloxy-5-bromonitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl phosphonomethanol | HCID 76513 | — |
| Reactant | 4-Bromo-1-fluoro-2-nitrobenzene | HCID 2736328 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Diethylphosphonomethyloxy-5-bromonitrobenzene | HCID 53916286 | — |
Reaction Steps
A solution of 2-fluoro-5-bromonitrobenzene (1 mmole) in DMF (5 mL) was cooled to 0° C., and treated with a solution of freshly prepared sodium salt of diethylhydroxymethylphosphonate (1.2 mmole) in DMF (5 mL). The mixture was stirred at room temperature for 16 h. Evaporation, extraction and chromatography provided 2-diethylphosphonomethyloxy-5-bromonitrobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489476B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-9bfabf87e297465984abc36cf55e6e1b |
| Source note | uspto-grants-2002_12 |