HCID 53772768, compound → HCID 53832899, compound

Participants

Reaction Steps

A solution of 2-diethylphosphonomethyloxy-5-formylnitrobenzene (1 mmole) in methanol (5 mL) was treated with 10% palladium on carbon (0.05 mmole) under 1 atmosphere of hydrogen at room temperature for 12 h. Filtration followed by evaporation gave 2-diethylphosphonomethyloxy-5-hydroxymethylaniline which was subjected to Step B of Example 36 followed by Step D of Example 34 to give 2-amino-7-hydroxymethyl-6-thiocyanato-4-phosphonomethoxybenzothiazole (39.1). mp 181-184° C. Anal. Calcd. for C10H10N3O5PS2+0.35H2O: C:33.97; H:3.05; N:11.88. Found: C:33.76; H:2.66; N:11.61.

Provenance & Evidence