HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-5-(2,6-dichlorobenzoyl)oxy-4-oxo pentanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-5-(2,6-dichlorobenzoyl) oxy-4-oxo pentanoic acid, tert-butyl ester | HCID 86756362 | — |
| Product | N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-5-(2,6-dichlorobenzoyl)oxy-4-oxo pentanoic Acid | HCID 70158742 | 60% |
Reaction Steps
Treatment of N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-5-(2,6-dichlorobenzoyl) oxy-4-oxo pentanoic acid, tert-butyl ester (63 mg, 0.089 mmol) with TFA as described in Example 80 gave the titled product (34.5 mg, 60%) as a white powder. MS C32H37Cl2N3O7, [M+H]+=646, [M−H]−=644. TLC (CH2Cl2/MeOH, 90/10): Rf=0.23.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489353B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-f692e9176fac4e31a5b3068b0cb026fe |
| Source note | uspto-grants-2002_12 |