Bis(2-amino-1H-imidazole) sulphate → HCID 18334319, compound

Participants

Reaction Conditions

Reaction Steps

1-(2-(5-Oxo-imidazo[1,2-a]pyrimidin-7-yl)ethyl)-5-ethoxycarbonylindazole. A mixture of the product prepared according to Example E-19 Part F (665 mg, 2.0 mmol), 2-aminoimidazole sulfate (291 mg, 2.2 mmol) and ammonium acetate (340 mg, 4.4 mmol) was heated on an oil bath at 150° C. After 2 h, the mixture was cooled and triturated in ethanol. The resulting solid was collected by filtration, washed with ethanol and dried to provide the title product (459 mg, 65%) as a gray-tan powder: 1H NMR (DMSO-d6) d 12.7 (bs, 1H), 8.44 (s, 1H), 8.25 (s, 1H), 7.88 (d, 1H), 7.71 (d, 1H), 7.52 (s, 1H), 7.47 (s, 1H), 5.69 (s, 1H), 4.80 (t, 2H), 4.32 (q, 2H), 3.10 (t, 2H), 1.33 (t, 3H); High resolution mass spectrum (NH3-CI) calculated (M+H+) 351.1331, found 351.1325.

Provenance & Evidence