HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(1,3-oxazol-5-yl)benzoate → 4-(1,3-Oxazol-5-yl)benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(1,3-oxazol-5-yl)benzoate | HCID 1477779 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 4-(1,3-Oxazol-5-yl)benzoic Acid | HCID 2776414 | — |
Reaction Steps
The above ester was heated at reflux for 2 hours in a mixture of 1 M aqueous potassium hydroxide and 50 ml THF. The THF was removed in vacuo and the solution cooled, then acidified with 50% HCl to give 4-(1,3-oxazol-5-yl)benzoic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06489344B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-8af04f8652a544f1999d4375036da919 |
| Source note | uspto-grants-2002_12 |