反应详情

The tert-butyl 6-chloropyridine-3-carboxylate was heated with ethylenediamine (20 ml) at 80° C. overnight. The solvent was removed in vacuo. The residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution. The aqueous layer was extracted a further three times with dichloromethane. The combined organic layers were washed with water, dried and concentrated in vacuo to give tert-butyl 6-[(2-aminoethyl)amino]pyridine-3-carboxylate.

1. customThe solvent was removed in vacuo
2. customThe residue was partitioned between dichloromethane and 2.5 M aqueous sodium hydroxide solution
3. extractionThe aqueous layer was extracted a further three times with dichloromethane
4. washThe combined organic layers were washed with water
5. customdried
6. concentrationconcentrated in vacuo