6-chloro-N-methyl-3-nitropyridin-2-amine → [4-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-yl](2-{[6-(methylamino)-5-nitro(2-pyridyl)]amino}ethyl)amine

HRID 2297186Notes

Reaction equation

HRID 2297186 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([C:15]2[NH:16][CH:17]=[CH:18][N:19]=2)=[CH:13][N:12]=[C:11](CCN)[N:10]=1.Cl[C:24]1[N:29]=[C:28]([NH:30][CH3:31])[C:27]([N+:32]([O-:34])=[O:33])=[CH:26][CH:25]=1.CO[C:37]1[N:42]=C(NCCN)C=C[C:38]=1[N+:47]([O-])=O>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([C:15]2[NH:16][CH:17]=[CH:18][N:19]=2)=[CH:13][N:12]=[C:11]([NH:42][CH2:37][CH2:38][NH:47][C:24]2[CH:25]=[CH:26][C:27]([N+:32]([O-:34])=[O:33])=[C:28]([NH:30][CH3:31])[N:29]=2)[N:10]=1

Participants

4

Reactant 3

HCID 107500946-chloro-N-methyl-3-nitropyridin-2-amineHCID 542317734-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-ylethylamineHCID 69485063HCID 69485063, compound

Product 1

HCID 22142846[4-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-yl](2-{[6-(methylamino)-5-nitro(2-pyridyl)]amino}ethyl)amine

Procedure

[4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl](2-{[6-(methylamino)-5-nitro(2-pyridyl)]amino}ethyl)amine was prepared from [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-ylethylamine and 6-chloro-2-methylamino-3-nitro-pyridine in accordance with the procedure described above for the preparation of [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{(2-[(6-methoxy-5-nitro(2-pyridyl))amino]-ethyl}amine.

Sources & evidence

ORD record
ord-c5cfbd6b63044e97970d2e39b578fa4e
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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