反应详情

温度

10 °C

To a methanol solution (1.2 L) of (5S,7S)-5-(N-(tert-butoxycarbinyl)-D-phenylalanyl)oxy-7-methyl-3-(3-trifluoromethylphenyl)-5,6,7,8-tetrahydrocinnoline (280 g, 0.5 mol) obtained in Example 54 was added a 1N NaOH aqueous solution (0.6 L) at room temperature, followed by reaction at 40° C. over night. The reaction liquid was cooled to 10° C., followed by adding distilled water (1.8 L), stirring under suspension for 4 hours and filtering crystal to obtain the titled compound. Thus obtained compound was the same one obtained in Example 10.

1. customfollowed by reaction at 40° C. over night
2. customThe reaction liquid
3. additionby adding
4. distillationdistilled water (1.8 L)
5. filtrationfiltering crystal