Chir-98023 → [4-(4-Chloro-2-methylphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

HRID 2297252Notes

Reaction equation

HRID 2297252 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([CH3:11])[CH:3]=1.ClC1C=C(Cl)C=CC=1C1[C:25]([C:26]2[NH:27][CH:28]=[CH:29][N:30]=2)=[CH:24][N:23]=[C:22]([NH:31][CH2:32][CH2:33][NH:34][C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][N:36]=2)[N:21]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:25]([C:26]3[NH:30][CH:29]=[CH:28][N:27]=3)=[CH:24][N:23]=[C:22]([NH:31][CH2:32][CH2:33][NH:34][C:35]3[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][N:36]=3)[N:21]=2)=[C:4]([CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 9847557Chir-98023HCID 128464844-Chloro-2-methylbenzoyl chloride

Product 1

HCID 22142860[4-(4-Chloro-2-methylphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine

Procedure

[4-(4-chloro-2-methylphenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine was prepared from 4-chloro-2-methylbenzoyl chloride using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-ce63f885076b44619601d330232b1655
Source dataset
uspto-grants-2002_12
Patent number
US06489344B1

Reaction notes

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