Acetic Acid → HCID 54011543, compound

Participants

Reaction Steps

To a stirred solution of (R)-3-[benzyl-((R)-1-phenylethyl)amino]-5-(4′-heptyloxy-biphenyl-4-yl)pentanoic acid tert-butyl ester (2.82 g, 4.45 mmol) in EtOAc (50 ml) were added AcOH (2.5 ml) and Pd(OH)2 on carbon (Pd(OH)2 ca. 20 wt %, 1.07 g), and then the mixture was set under H2 atmosphere. After being stirred for 15 h, the mixture was filtered through a pad of Celite and washed with MeOH. The filtrate and washings were combined, and concentrated in vacuo to give (R)-3-amino-5-(4′-heptyloxybiphenyl-4-yl)pentanoic acid tert-butyl ester (crude, 3.14 g) which was used for the next step without further purification.

Provenance & Evidence