Formic Acid → HCID 131723672, compound

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Reaction Steps

To a solution of toremifene base (1.00 g, 0.0025 moles) and refluxing diethyl ether (14 ml) was slowly added formic acid (100 μl, 0.0027 moles). The refluxing mixture was stirred for a while and cooled to room temperature. The mixture was stirred additional 30 min at room temperature. The salt was crystallised at −15° C. for 36 hours. After filtration the formate of toremifene was obtained (yield 78%) having melting point of 147° C. 1H-NMR (d6-DMSO) d 8.19 (s, 1H), 7.39 (t, 2H), 7.35-7.27 (m, 3H), 7.27-7.12 (m, 5H), 6.76 (d, 2H), 6.62 (d, 2H), 3.95 (t, 2H), 3.43 (t, 2H 2.85 (t, 2H), 2.70 (t, 2H), 2.28 (s, 6H).

Provenance & Evidence