2,3,5,5-Tetrafluoro-6-(6-hexyloxypyridin-3-yl)-5,6,7,8-tetrahydronaphthalen-1-ol → 2-Hexyloxy-5-[1,1,6,7-tetrafluoro-5-(2-fluorodecyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]pyridine

HRID 2297346Notes

Reaction equation

HRID 2297346 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:8]([F:14])([F:13])[CH:7]([C:15]3[CH:16]=[N:17][C:18]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:19][CH:20]=3)[CH2:6][CH2:5][C:4]=2[C:3]=1[OH:28].[F:29][C@@H:30]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH2:31]O>>[CH2:22]([O:21][C:18]1[CH:19]=[CH:20][C:15]([CH:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][C:11]([F:12])=[C:2]([F:1])[C:3]=3[O:28][CH2:31][CH:30]([F:29])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:8]2([F:14])[F:13])=[CH:16][N:17]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 183810942,3,5,5-Tetrafluoro-6-(6-hexyloxypyridin-3-yl)-5,6,7,8-tetrahydronaphthalen-1-olHCID 22857780HCID 22857780, compound

Product 1

HCID 183811132-Hexyloxy-5-[1,1,6,7-tetrafluoro-5-(2-fluorodecyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl]pyridine

Procedure

From 2,3,5,5-tetrafluoro-6-(6-hexyloxypyridin-3-yl)-5,6,7,8-tetrahydronaphthalen-1-ol and 2-(S)-fluorodecan-1-ol by means of the Mitsunobu reaction.

Sources & evidence

ORD record
ord-3c9a6517613f43d395c8a8af39a383b1
Source dataset
uspto-grants-2002_12
Patent number
US06491989B1

Reaction notes

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