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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2297347Generated: October 25, 2026

2,3-Epoxyhexanol → 5-Hexyloxy-2-[1,1,6,7-tetrafluoro-5-(3-propyloxiranylmethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine

https://huagongshe.com/reaction/2297347

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-EpoxyhexanolHCID 543565—
Reactant2,3,5,5-Tetrafluoro-6-(5-hexyloxypyrimidin-2-yl)-5,6,7,8-tetrahydronaphthalen-1-olHCID 18381110—
Product5-Hexyloxy-2-[1,1,6,7-tetrafluoro-5-(3-propyloxiranylmethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidineHCID 18381123—

Reaction Steps

From 2,3,5,5-tetrafluoro-6-(5-hexyloxypyrimidin-2-yl)-5,6,7,8-tetrahydronaphthalen-1-ol and (3-propyloxiranyl)methanol by means of the Mitsunobu reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06491989B1
Source datasetuspto-grants-2002_12
ORD IDord-fcf874d6b5414b35ad6b19fd2600e082
Source noteuspto-grants-2002_12