Ammonium Chloride → HCID 15422793, compound

Participants

Reaction Steps

To a tetrahydrofuran solution of 1.0M methylmagnesium chloride under ice cooling was added dropwise 14.2 g of 4,4-dimethyl-4-silacyclohexanone (which is synthesized by the disclosure of JP-A 7-309878). After two hours of agitation, an aqueous solution of ammonium chloride was added for hydrolysis. After ordinary post-treatments including extraction, washing and concentration, the product was purified by sublimation, obtaining 14.2 g (yield 90%) of 1,4,4-trimethyl-4-silacyclohexanol.

Provenance & Evidence