反应详情

4.5 g (0.02 mol) of benzyl p-hydroxybenzoate were suspended in about 60 ml of acetone together with 9.7 g (0.03 mol) of cesium carbonate and treated with 2.3 ml (0.025 mol) of ethyl bromoacetate. The mixture was then refluxed until reaction was complete. For working-up, the reaction solution was filtered through a clarifying layer and the filtrate was concentrated to dryness. The residue was taken up in ethyl acetate and the mixture was washed three times each with 10% strength citric acid solution and saturated NaCl solution. The organic phase was dried over sodium sulfate, filtered and concentrated. The residue was recrystallized from diisopropyl ether/heptane. Yield: 5.5 g.

1. temperatureThe mixture was then refluxed until reaction
2. filtrationthe reaction solution was filtered through a clarifying layer
3. concentrationthe filtrate was concentrated to dryness
4. washthe mixture was washed three times each with 10% strength citric acid solution and saturated NaCl solution
5. dry with materialThe organic phase was dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was recrystallized from diisopropyl ether/heptane