HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S)-2-Benzyloxycarbonylamino-3-(4-((1,4, 5,6-tetrahydropyrimidin-2ylcarbamoyl)methyloxy)benzoylamino)propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (2s)-2-benzyloxycarbonylamino-3-(4-((1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)methyloxy)benzoylamino)propionate | HCID 57208730 | — |
| Product | (2S)-2-Benzyloxycarbonylamino-3-(4-((1,4, 5,6-tetrahydropyrimidin-2ylcarbamoyl)methyloxy)benzoylamino)propionic Acid | HCID 57222079 | — |
Reaction Steps
87 mg of the tert-butyl ester obtained in step d) were stirred at room temperature for 15 min in 2 ml of 95% strength trifluoroacetic acid. After concentrating in vacuo, the mixture was triturated with ether, and the residue was filtered off and dried. Yield: 79 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492356B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-a48b44be5610419291dd0d809fcaff74 |
| Source note | uspto-grants-2002_12 |