HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(3,5-Dichloro-pyridin-4-ylmethyl)-4-ethyl-6-methoxy-phthalazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3,5-Dichloro-4-methylpyridine | HCID 10953827 | — |
| Reactant | 1-Chloro-4-ethyl-6-methoxy-phthalazine | HCID 18381645 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3,5-Dichloro-pyridin-4-ylmethyl)-4-ethyl-6-methoxy-phthalazine | HCID 9928261 | 36% |
Reaction Steps
Operating substantially as described in example 5 starting from 3,5-dichloro-4-methyl-pyridine (1.75 g, 10.77 mmoles), dry DMF (20 ml), 60% NaH in oil (0.26 g, 10.77 mmoles) and 1-chloro-4-ethyl-6-methoxy-phthalazine (1.2 g, 5.39 mmoles), prepared as described in example 10, in DMF (25 ml), 0.66 g of the title compound were obtained (yield: 36%). m.p.: 136-138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492360B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-396c93e6e15542618a563ee89cbac981 |
| Source note | uspto-grants-2002_12 |