Hydrazine → 5-Hydroxy-6-methoxy-2H-phthalazin-1-one

HRID 2297440ノート

反応式

HRID 2297440 の反応式
O[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:12][CH3:13])[C:9]=2[OH:11])[C:4](=O)[O:3]1.[NH2:15][NH2:16]>C(O)C>[OH:11][C:9]1[C:8]([O:12][CH3:13])=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:2]=[N:15][NH:16][C:4]2=[O:3]

参加物

4

反応物 2

HCID 9321HydrazineHCID 185047873,4-Dihydroxy-5-methoxy-3H-isobenzofuran-1-one

生成物 1

HCID 1355563055-Hydroxy-6-methoxy-2H-phthalazin-1-one収率 72%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3,4-dihydroxy-5-methoxy-3H-isobenzofuran-1-one (6.63 g, 34 mmoles), prepared as described in example 57, in ethanol (60 ml) was added with 98% hydrazine (8.5 ml). The mixture was heated to clarity and after 5 minutes a precipitate formed and was filtered and treated with 1N HCl. The mother liquors were concentrated more times and the resultant solid fractions joined to give 4.65 g of the title compound (yield: 72%).

後処理

  1. temperatureThe mixture was heated to clarity and after 5 minutes a precipitate
  2. customformed
  3. filtrationwas filtered
  4. additiontreated with 1N HCl
  5. concentrationThe mother liquors were concentrated more times

出典と根拠

ORDレコード
ord-49376c41a8684afd9e87536e30d5fc7c
出典データセット
uspto-grants-2002_12
特許番号
US06492360B1

反応ノート

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