Phosphorus oxychloride → HCID 54335011, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-methoxy-5-phenylethynyl-2H-phthalazin-1-one (0.67 g, 2.42 mmoles), prepared as described in example 60, in POCl3 (20 ml) was heated at 80° C. under stirring up to dissolution. After 30 minutes the solution was brought to dryness and the residue taken up in CH2Cl2 (100 ml), washed to alkalinity with a solution of K2CO3, then with water, then anhydrified over Na2SO4 and evaporated to give 715 mg of the title compound (quantitative yield). The compound was used as such in the subsequent step.

Provenance & Evidence