Hydrochloric Acid → HCID 87219412, compound

Participants

Reaction Conditions

Reaction Steps

25 ml of a solution of gaseous hydrochloric acid (4.5 M) in ethyl acetate are added dropwise at 0° C. to 5 g of tert-butyl(1S)-2-[(5-{2-[(phenoxy)-methyl]phenyl}-1,3-thiazol-2-yl)amino]-1-propyl-2-oxoethylcarbamate, obtained in step 1.6, in solution in 60 ml of ethyl acetate. The mixture is stirred for 18 hours at 20° C. The precipitate formed is filtered, rinsed twice with diethyl ether and dried to give 3 g of a white solid.

Provenance & Evidence