HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 4-(4-Chloro-6-methoxy-phthalazin-1-yl)-butyric acid methyl ester | HCID 54269100 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 4-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-butyric acid methyl ester | HCID 54370004 | 26.1% |
Reaction Steps
Operating analogously at what described in example 48 starting from 4-(4-chloro-6-methoxy-phthalazin-1-yl)-butyric acid methyl ester (12.5 g, 0.0424 mole), prepared as described in example 114, zinc (17.3 g), 2-bromothiazole (24.3 g, 0.1484 mole), palladium acetate (0.476 g, 2.12 mmole), triphenylphosphine (1.67 g, 6.36 mmole), 3.8 g of the title compound were obtained (yield: 12.6%). m.p.: 136-137° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492360B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-76c8b64719f74a9082d831b215336391 |
| Source note | uspto-grants-2002_12 |