참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Malonic Acid | HCID 867 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (2E)-3-(3-Thienyl)-2-propenoic acid | HCID 735793 | — |
반응 단계
46 g of malonic acid and 2 ml of piperidine are added to 25 g of 3-thienaldehyde in solution in 100 ml of pyridine, and the mixture is heated at 100° C. for 4 hours. The reaction medium is cooled to 30° C. and it is poured over an aqueous hydrochloric acid solution (2N). The precipitate formed is filtered and it is rinsed with isopropyl ether to give, after drying, 30 g of a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07563903B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-b2dadde8643543a490e837c105152953 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
