HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 3-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester | HCID 86757648 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester | HCID 54041221 | 26.6% |
Reaction Steps
Operating analogously at what described in example 48 starting from 3-(4-chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester (4.5 g, 0.0153 mole), prepared as described in example 121, zinc (2.2 g), 2-bromothiazole (5 g, 0.0305 mole), palladium acetate (180 mg, 0.8 mmole), triphenyphosphine (630 mg, 2.4 mmoles), 1.4 g of the title compound were obtained (yield: 21%). m.p.: 153-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492360B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-046a365cb06e48bcad789c2ddf569e29 |
| Source note | uspto-grants-2002_12 |