4-Phenoxybenzaldehyde → HCID 18381922, compound

Participants

Reaction Steps

4-phenoxybenzaldehyde (989 mg) and 1-acetylpiperazine (713 mg) were dissolved in 1,2-dichloroethane (11 ml), and sodium triacetoxyboro hydride (1.60 g) and acetic acid (300 mg) were added. The atmosphere was replaced with argon and the mixture was stirred at room temperature for 7 hours. Water (5 ml) and aqueous saturated sodium hydrogen carbonate solution (20 ml) were added and the mixture was extracted 5 times with chloroform. Organic layers were combined and dried over anhydrous sodium sulfate. Chloroform was removed and the residue was purified by silica gel column chromatography (ethyl acetate-ethyl acetate:methanol=20:1-10:1) to quantitatively obtain 1.55 g of 1-acetyl-4-(4-phenoxybenzyl)piperazine.

Provenance & Evidence