Water → HCID 3559741, compound

HRID 2297516Notes

Reaction equation

HRID 2297516 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[K+].O>C(O)C>[O:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[CH:12][CH:13]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 18381922HCID 18381922, compound

Product 1

HCID 3559741HCID 3559741, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-acetyl-4-((4-phenoxyphenyl)methyl)piperazine (316 mg) was dissolved in ethanol (20 ml), and aqueous potassium hydroxide solution (3 ml, potassium hydroxide 1 g) was added, followed by heating the mixture to reflux for 4 hours. Water was added to the reaction mixture and the mixture was extracted 3 times with chloroform. Organic layers were combined and dried over anhydrous sodium sulfate, followed by removal of chloroform to obtain 267 mg of 1-((4-phenoxyphenyl)methyl)piperazine. Yield: 98%.

Workup

  1. temperatureby heating the mixture
  2. temperatureto reflux for 4 hours
  3. extractionthe mixture was extracted 3 times with chloroform
  4. dry with materialdried over anhydrous sodium sulfate
  5. customfollowed by removal of chloroform

Sources & evidence

ORD record
ord-f531c22c23b94edcb76a8dde4755167a
Source dataset
uspto-grants-2002_12
Patent number
US06492364B1

Reaction notes

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