Isatoic Anhydride → HCID 86758637, compound

Participants

Reaction Steps

Isatoic anhydride (1.02 g) and 1-diphenylmethyl-4-(3-aminopropyl)piperazine (2.12 g) were dissolved in 1,4-dioxane (20 ml) and the mixture was stirred at room temperature for 4 hours. 1,4-dioxane was removed and the residue was purified by silica gel column chromatography (ethyl acetate), followed by recrystallization of the resultant from ethyl acetate-hexane to obtain 2.47 g of N-(3-(4-(diphenylmethyl)piperazinyl)propyl)(2-aminophenyl)formamide. Yield: 92%.

Provenance & Evidence