Ethanol → HCID 178517138, compound

Participants

Reaction Steps

Under argon atmosphere, 3-(3-hydroxyquinoxaline-2-yl)-1-(4-(diphenylmethyl)piperidyl)propane-1-one (700 mg) was dissolved in tetrahydrofuran (17 ml), and lithium aluminum hydride (100 mg) was added to the solution, followed by stirring the mixture overnight at room temperature and then at 60° C. for 2 hours. Ethanol and saturated aqueous sodium sulfate solution were added to the reaction mixture under cooling in ice, and the generated precipitates were removed by filtration, followed by concentrating the filtrate. The residue was purified by Chromatorex® Column for amines (ethyl acetate) to obtain 387 mg of 3-(3-(4-(diphenylmethyl)piperidyl)propyl)quinoxaline-2-ol. Yield: 57%.

Provenance & Evidence