6-Chloronaphthalene-2-sulfonyl chloride → HCID 18382260, compound

Participants

Reaction Steps

Similarly to Example 1, reaction of 3-[4-(5-methyl[1,2,4]oxadiazol-3-yl)phenyl]-1-piperazin-1-ylpropan-1-one [obtainable from 3-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]-1-(4-tert-butyloxycarbonyl)piperazin-1-yl-propan-1-one by treatment with TFA/CH2Cl2] and 6-chloronaphthalene-2-sulphonyl chloride gives the compound 1-[4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-yl]-3-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl]propan-1-one and, after hydrogenation, 4-{3-oxo-3-[4-(6-chloronaphthalene-2-sulphonyl)piperazin-1-yl]propyl}benzamidine.

Provenance & Evidence