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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2297547Generated: October 30, 2026

tert-Butyl piperazine-1-carboxylate → HCID 18382134, compound

https://huagongshe.com/reaction/2297547

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
ReactantHCID 18382102HCID 18382102—
SolventTolueneHCID 1140—
ProductHCID 18382134HCID 18382134—

Reaction Steps

Heating with BOC-piperazine in toluene gives in a rearrangement reaction, after customary work-up, 1-BOC-4-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylcarbamoyl]-piperazine. Removal of the BOC group with TFA in CH2C2 gives 4-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenyl-carbamoyl]piperazine (“C”).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06492368B1
Source datasetuspto-grants-2002_12
ORD IDord-d139187666b24374aed30b4dd3a5052b
Source noteuspto-grants-2002_12