L-Tyrosine 1,1-dimethylethyl ester → HCID 178467516, compound

HRID 2297579Notes

Reaction equation

HRID 2297579 reaction equation
C(O[C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:13])(=[O:12])[N:5]=1)C.[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH2:21])([CH3:17])([CH3:16])[CH3:15]>C(O)C>[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:21][C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:12])(=[O:13])[N:5]=1)([CH3:17])([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 6950582L-Tyrosine 1,1-dimethylethyl esterHCID 112179953,4-Diethoxy-1,2,5-thiadiazole-1,1-dioxide

Product 1

HCID 178467516HCID 178467516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3,4-diethyloxy—1,1-dioxo—1,2,5-thiadiazole (400 mg, 1.94 mmol) and L-tyrosine t-butyl ester (1.25 g, 5.2 mmol) in ethanol (25 mL) was stirred at room temperature overnight. Solvent was removed under reduced pressure and the product used in further transformations without further purification (Yield 790 mg).

Workup

  1. customSolvent was removed under reduced pressure
  2. customthe product used in further transformations without further purification (Yield 790 mg)

Sources & evidence

ORD record
ord-be9075f0f85145428de3a470a81e9bf8
Source dataset
uspto-grants-2002_12
Patent number
US06492372B1

Reaction notes

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