Potassium Cyanide → HCID 18382508, compound

Participants

Reaction Steps

0.46 g of 6-benzyl-2-bromomethyl-7-cyclopentyl-4-ethyl-imidazo[4.5-e]-s-triazolo[1.5-a]pyrimidin-5-one (for preparation see Synthesis example 1) are added to a solution of 0.72 g of KCN in 0.7 ml of water and 2.4 ml of ethanol heated to boiling. The mixture is boiled for a further 30 minutes until the reaction is complete. For working up the mixture is diluted with 10 ml of water and extracted with 15 ml of dichloromethane. The organic phase is separated off, washed with saturated sodium chloride solution and dried over magnesium sulphate. The solvent is distilled off and the residue remaining is purified by chromatography on silica gel (dichloromethane:methanol 99:1). 0.3 g of the title compound is obtained in the form of a colourless solid.

Provenance & Evidence