2,4,4-Trimethyl-7-nitroisoquinoline-1,3(2H,4H)-dione → HCID 18382709, compound

Participants

Reaction Steps

7-Nitro-2,4,4-trimethyl4H-isoquinoline-1,3-dione (45 g, 20 mmol) was dissolved in a methanol (500 ml)/dichloromethane (100 ml) mixture and treated with 10% Pd/C (0.5 g). The reaction mixture was hydrogenated for 2 h before removal of the palladium catalyst by filtration through Celite. The filtrate was evaporated to dryness in vacuo to give the title compound (4.4 g, quant). 1H NMR (250 MHz, CDCl3)≃:1.58 (6H, s), 3.36 (3H, s), 3.83 (2H, brs), 6.95 (1H, dd, J=6, 3 Hz), 7.24 (1H, d, J=6 Hz), 7.48 (1H, d, J=3 Hz); m/z (API+): 219 (M+H)+

Provenance & Evidence