Methyl iodide → 7-Amino-2-methyl-3,4-dihydroisoquinolinium iodide

HRID 2297611Notes

Reaction equation

HRID 2297611 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[I:12][CH3:13]>CC(C)=O>[I-:12].[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N+:8]([CH3:13])=[CH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 114236673,4-Dihydroisoquinolin-7-amine

Product 1

HCID 111089627-Amino-2-methyl-3,4-dihydroisoquinolinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

7-Amino-3,4-dihydroisoquinoline (0.40 g, 2.74 mmol) in acetone (125 ml) was treated with iodomethane (0.50 ml, 8.03 mmol) and left stirring at room temperature for 18 h. The resultant yellow precipitate was collected by filtration and dried in vacuo (0.73 g, 92%).

Workup

  1. waitleft
  2. filtrationThe resultant yellow precipitate was collected by filtration
  3. customdried in vacuo (0.73 g, 92%)

Sources & evidence

ORD record
ord-6bdab40d9a84482eaeea4e2e2c29e22c
Source dataset
uspto-grants-2002_12
Patent number
US06492378B1

Reaction notes

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