HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2297618Generated: October 31, 2026
Isopropyl iodide → Methyl 3-bromo-4-isopropoxybenzoate
https://huagongshe.com/reaction/2297618
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-bromo-4-hydroxybenzoate | HCID 4778958 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-bromo-4-isopropoxybenzoate | HCID 21956810 | 101.7% |
Reaction Steps
Methyl 3-bromo-4-hydroxybenzoate (2.5 g, 10.8 mmol) in DMF (35 ml) was treated with potassium carbonate (3.0 g, 21.6 mmol), 2-iodopropane (2.76, 21.6 mmol) and then stirred at 25° C. for 48 h. Work-up with ethyl acetate gave the title compound (3.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06492378B1 |
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| Source dataset | uspto-grants-2002_12 |
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| ORD ID | ord-76e65f6c1350448e820458e2525f7367 |
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| Source note | uspto-grants-2002_12 |
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