HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Methyl 3-cyano-4-isopropoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methyl 3-bromo-4-isopropoxybenzoate | HCID 21956810 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Methyl 3-cyano-4-isopropoxybenzoate | HCID 21956805 | — |
Reaction Steps
Methyl 3-bromo-4-iso-propoxybenzoate (2.0 g, 7.3 mmol) and copper(I)cyanide in N-methyl pyrrolidone (50 ml) was heated under vigorous reflux for 4 h. Work-up with ethyl acetate gave the title compound (1.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492378B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-4f699537d7ef4bff9e2ae2d73df322c5 |
| Source note | uspto-grants-2002_12 |