Potassium Carbonate → HCID 11281004, compound

Participants

Reaction Steps

A mixture of “AB” and 4-chloro-2-isopropyl-3H-imidazo[4,5-c]pyridine is found in the mother liquor. A solution of 0.877 g of “AB” and 0.691 g of potassium carbonate in 30 ml of DMF is stirred at room temperature for 30 minutes. 1.5 g of 3-(7-bromomethylnaphthalen-2-yl)-5-methyl[1,2,4]oxadiazole (m.p. 149-150°) are added and the mixture is stirred for 16 hours and worked up in the customary manner. After chromatography on silica gel, in addition to the two regioisomeric dialkylation products, the compound 2-isopropyl-3-[7-(5-methyl[1,2,4]oxadiazol-3-yl)naphth-2-ylmethyl]-5H-imidazo[4,5-c]pyridin-4-one (“BB”), m.p. 214-215° EI 399 is obtained

Provenance & Evidence