HCID 59923438, compound → HCID 59923455, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 20% palladium hydroxide on carbon (30 mg) is added to a solution of (2S)-2-[3-[2-(benzyloxy)ethyl]-1-isoamylureido]-N-[2-(dimethylamino)ethyl]-3-phenylpropionamide (Compound No. 21-1, 300 mg) in methanol (10 ml). The mixture is stirred under a hydrogen atmosphere for 4.5 hours. Palladium hydroxide on carbon is filtered out with Celite, and the filtrate is concentrated under reduced pressure. The concentrate is dissolved in ethyl acetate. The solution is washed with a 10% aqueous sodium hydrogencarbonate solution, water and saturated brine successively, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting oily matter is purified by silica gel column chromatography to give 167 mg (68%) of the titled compound (Compound No. 22-1).

Provenance & Evidence