HCID 59923450, compound → HCID 59923476, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, 5% palladium-carbon (92 mg) is added to a solution of (2S)-N-[2-(dimethylamino)ethyl]-2-[3-(2-hydroxyethyl)-3-phenethylureido]-3-(4-nitrophenyl)propionamide (Compound No. 19-1, 921 mg) in ethanol (30 ml). The mixture is stirred under a hydrogen atmosphere for three hours. Palladium-carbon is filtered out with Celite, and the filtrate is concentrated under reduced pressure. The resulting oily matter is purified by silica gel column chromatography to give 418 mg (49%) of the titled compound (Compound No. 24-1) as noncrystalline powder.

Provenance & Evidence