Fumaric Acid → HCID 86586960, compound

Participants

Reaction Steps

1-[(2S)-2-[3-[2-(Acetylthio)ethyl]-3-phenethylureido]-3-phenylpropionyl]-4-methylpiperazine (Compound No. 27-2, 16.39 g) is dissolved in ether (150 ml), and a solution of fumaric acid (3.83 g) in methanol (100 ml) is added thereto under ice cooling. The reaction mixture is concentrated under reduced pressure, the resulting oily matter is dissolved in diethyl ketone (40 ml), and the solution is allowed to stand in a refrigerator overnight to give 9.04 g (45%) of the titled compound (Compound No. 35-1) as crystals.

Provenance & Evidence