7-(Diethylamino)-2-oxo-2H-chromene-3-carbaldehyde → 1-(5-carboxy-pentyl)-2-[(E)-2-(7-diethylamino-2-oxo-2H-chromen-3-yl)-vinyl]-5-sulfonato-pyridinium Betaine

HRID 229775Notes

Reaction equation

HRID 229775 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([CH:15]=O)[C:10](=[O:14])[O:11]2)=[CH:6][CH:5]=1)[CH3:2].[C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][N+:27]1[CH:32]=[C:31]([S:33]([O-:36])(=[O:35])=[O:34])[CH:30]=[CH:29][C:28]=1[CH3:37])([OH:21])=[O:20].[CH3:38][N+:39]([CH2:42][C:43]([OH:45])=[O:44])([CH3:41])[CH3:40]>CO.O>[C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][N+:27]1[CH:32]=[C:31]([S:33]([O-:36])(=[O:35])=[O:34])[CH:30]=[CH:29][C:28]=1/[CH:37]=[CH:15]/[C:9]1[C:10](=[O:14])[O:11][C:12]2[C:7]([CH:8]=1)=[CH:6][CH:5]=[C:4]([N:3]([CH2:17][CH3:18])[CH2:1][CH3:2])[CH:13]=2)([OH:21])=[O:20].[CH3:38][N+:39]([CH2:42][C:43]([OH:45])=[O:44])([CH3:41])[CH3:40]

Participants

4

Reactant 2

HCID 1431917-(Diethylamino)-2-oxo-2H-chromene-3-carbaldehydeHCID 865891181-(5-Carboxy-pentyl)-2-methyl-5-sulfonato-pyridinium betaine

Product 1

HCID 865891171-(5-carboxy-pentyl)-2-[(E)-2-(7-diethylamino-2-oxo-2H-chromen-3-yl)-vinyl]-5-sulfonato-pyridinium Betaine

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

0.2 mmol 7-diethylamino-2-oxo-2H-chromene-3-carbaldehyde and 0.2 mmol 1-(5-carboxy-pentyl)-2-methyl-5-sulfonato-pyridinium betaine are converted according to the general directions above. Column chromatography: SiO2 (RP18), eluent: methanol/water.

Sources & evidence

ORD record
ord-429dc33c6b124f3db6be45bd19ce295d
Source dataset
uspto-grants-2009_07
Patent number
US07563907B2

Reaction notes

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