Tolylboronic acid → (1H-Indol-5-yl)-(6-p-tolyl-thieno[3,2-d]pyrimidin-4-yl)-amine

Participants

Role	Name	HCID	Charge
Reactant	Tolylboronic acid	HCID 79799	—
Reactant	(6-Bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine	HCID 18383051	—
Product	(1H-Indol-5-yl)-(6-p-tolyl-thieno[3,2-d]pyrimidin-4-yl)-amine	HCID 9798795	—

Reaction Steps

The title compound was prepared from p-methylbenzeneboronic acid and (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 2. 1H NMR (400 MHz, DMSO) d 11.1 (s, 1H), 9.50 (s, 1H), 8.41 (s, 1H), 7.71 (d, 2H), 7.59 (s, 2H), 7.24 (m, 5H), 6.38 (s, 1H), 2.28 (s, 3H). M.P. 200-220° C.; LC-MS: 357 (MH+); HPLC RT: 4.57 minutes.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06492383B1
Source dataset	uspto-grants-2002_12
ORD ID	ord-98291b74b15e4d44b587806ad954b66a
Source note	uspto-grants-2002_12