7-(Diethylamino)-2-oxo-2H-chromene-3-carbaldehyde → 1-(5-carboxy-pentyl)-4-[(E)-2-(7-diethylamino-2-oxo-2H-chromen-3-yl)-vinyl]-pyridinium Bromide

HRID 229776Notes

Reaction equation

HRID 229776 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([CH:15]=O)[C:10](=[O:14])[O:11]2)=[CH:6][CH:5]=1)[CH3:2].[Br-:19].[C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][N+:28]1[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=1)([OH:22])=[O:21]>C(O)C.C1(C)C=CC=CC=1>[Br-:19].[C:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][N+:28]1[CH:29]=[CH:30][C:31](/[CH:34]=[CH:15]/[C:9]2[C:10](=[O:14])[O:11][C:12]3[C:7]([CH:8]=2)=[CH:6][CH:5]=[C:4]([N:3]([CH2:17][CH3:18])[CH2:1][CH3:2])[CH:13]=3)=[CH:32][CH:33]=1)([OH:22])=[O:21]

Participants

4

Reactant 2

HCID 1431917-(Diethylamino)-2-oxo-2H-chromene-3-carbaldehydeHCID 179378181-(5-Carboxypentyl)-4-methylpyridin-1-ium bromide

Product 1

HCID 865891191-(5-carboxy-pentyl)-4-[(E)-2-(7-diethylamino-2-oxo-2H-chromen-3-yl)-vinyl]-pyridinium Bromide

Reagents, catalysts & solvents 1

HCID 21863594Toluene ethanolSolvent

Procedure

0.2 mmol 7-diethylamino-2-oxo-2H-chromene-3-carbaldehyde and 0.2 mmol 1-(5-carboxy-pentyl)-4-methyl-pyridinium bromide are converted according to the general directions above. Column chromatography: SiO2, eluent: ethanol/toluene.

Sources & evidence

ORD record
ord-00d496421695455da0101c79b663e1dd
Source dataset
uspto-grants-2009_07
Patent number
US07563907B2

Reaction notes

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